DAANBIOTHERAPEUTICS

l   Position : Scientist / Senior Scientist, T Cell Engager (TCE) Research Project Leaeder

l   Work locations: Seoul, South Korea

l   type: Full-time

l   Contact Information: daanbiotpx@daanbiotpx.com

[Responsibilities]

• Develop and execute in vitro assays for T cell engager (TCE) programs and contribute to platform establishment, including cancer cell culture, immune cell (PBMC/T cell) handling, and optimization of co-culture conditions
• Perform in vitro killing and effector function assays, including quantitative cytotoxicity assessments
• Lead experimental design and data-driven decision-making processes, from study design and execution to data interpretation and recommendation of next actions (optimization, deprioritization, or advancement)
• Drive assay robustness, reproducibility, and continuous improvement of TCE evaluation platforms

[Basic Qualifications (Required)]

• M.S. or Ph.D. in Biology, Immunology, Pharmacy, Biotechnology, or a related field
• Approximately 5 years of industry experience in immuno-oncology or antibody-based biologics research
• Strong expertise in cancer cell culture and cell-based assay design and execution
• Hands-on experience in T cell/PBMC co-culture-based in vitro killing assays with quantitative readouts
• Proficiency in flow cytometry for immune profiling (e.g., activation, exhaustion markers) and data analysis
• Demonstrated ability to optimize assay conditions, troubleshoot technical challenges, and ensure experimental reproducibility
• Self-driven, execution-focused mindset with strong ownership of projects and the ability to translate data into actionable decisions

[Preferred Qualifications]

• Hands-on experience in T cell engager (TCE) development, with a leading role in at least one stage from design to in vitro proof-of-concept (POC) and/or lead optimization
• Experience comparing different TCE formats and mechanisms, including affinity tuning, CD3 arm design, and safety considerations
• Advanced mechanism-of-action (MOA) characterization experience (e.g., phospho-flow, activation signaling analysis, immune synapse/engagement quantification, target density-dependent activity assessment)
• Experience evaluating cytokine release and over-activation risks from an in vitro safety perspective
• Track record of scientific achievements, including publications and/or patents
• Experience in regulatory documentation for TCE or immuno-oncology antibody programs, including FDA and/or MFDS IND submissions
• Eligibility for the Korean Alternative Military Service Program (Specialized Research Personnel) and ability to work in Korea
• Fluency in English for global scientic communication and publications is required; additional proficency in Korean is a plus

[Documents for Application]

• CV/Resume with a cover letter

[Salary & Benefits]

• Competitive and commensurate with experience and qualifications
• Additional benefits will be discussed during the interview process